Clandinin Lab
  • Home
  • Equity Statement
  • Our Research
    • Visual Computation
    • Tool Building
    • Neurodegeneration
  • People
    • Current Lab Members
    • Alumni
  • Publications
  • Contact

Tool Building

Picture


Integral to our ability to dissect neural circuits at the cellular and molecular level is the generation of new tools.  Previous work in the lab developed a new genetic system for cell-type specifically controlling gene expression patterns.  This system, the InSite system allowed us to express proteins that manipulate neural activity in specific visual neurons, enabling us to do a forward genetic screen to identify neural components important for motion processing.  These screens identified a number of new cellular components involved in motion processing, opening them for functional and physiological characterization. 

At present, we are working on three different types of tools, including high-speed voltage imaging using genetically encoded indicators, new tools for cell-type specifically disrupting genes, and tools for mapping electrical synaptic connections. 


Order InSITE lines from Bloomington

Detailed InSITE information from Bloomington

The InSITE Database

Powered by Create your own unique website with customizable templates.